Precise Photodynamic Therapy of Cancer via Subcellular Dynamic Tracing of Dual-loaded Upconversion Nanophotosensitizers

Sci Rep. 2017 Mar 31:7:45633.  doi: 10.1038/srep45633.

Precise Photodynamic Therapy of Cancer via Subcellular Dynamic Tracing of Dual-loaded Upconversion Nanophotosensitizers

Yulei Chang 1, Xiaodan Li 1 2, Li Zhang 1 2, Lu Xia 1, Xiaomin Liu 1, Cuixia Li 1, Youlin Zhang 1, Langping Tu 1 3, Bin Xue 1 3, Huiying Zhao 2, Hong Zhang 3, Xianggui Kong 1

Abstract

Recent advances in upconversion nanophotosensitizers (UCNPs-PS) excited by near-infrared (NIR) light have led to substantial progress in improving photodynamic therapy (PDT) of cancer.  For a successful PDT, subcellular organelles are promising therapeutic targets for reaching a satisfactory efficacy.  It is of vital importance for these nanophotosensitizers to reach specifically the organelles and to perform PDT with precise time control.  To do so, we have in this work traced the dynamic subcellular distribution, especially in organelles such as lysosomes and mitochondria, of the poly(allylamine)-modified and dual-loaded nanophotosensitizers.  The apoptosis of the cancer cells induced by PDT with the dependence of the distribution status of the nanophotosensitizers in organelles was obtained, which has provided an in-depth picture of intracellular trafficking of organelle-targeted nanophotosensitizers.  Our results shall facilitate the improvement of nanotechnology assisted photodynamic therapy of cancers.
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